I find "Austin Powers", where Mike Myers plays numerous roles, to be self-indulgent and obnoxious.
"Alex and Emma" and "Joe versus the Volcano" feature Kate Hudson and Meg Ryan, respectively. Each movie has them portraying many characters. And those movies I enjoy. And then there's "Dead Again", with Emma and Kenneth, each playing two roles.
Maybe I just grew tired of Mike Myers sometime during Wayne's World 2.